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  • Title: Alpha 1-antitrypsin in patients with hepatocellular carcinoma and chronic active hepatitis.
    Author: Fargion S, Klasen EC, Lalatta F, Sangalli G, Tommasini M, Fiorelli G.
    Journal: Clin Genet; 1981 Feb; 19(2):134-9. PubMed ID: 6258829.
    Abstract:
    Forty-seven Italian patients suffering from hepatocellular carcinoma (HCC) and 58 patients with chronic active hepatitis (CAH) were screened for alpha 1-antitrypsin (alpha 1 AT) levels and types and compared with a previously screened healthy Italian population. Serum alpha 1 AT concentrations were significantly raised among the HCC patients compared to the controls, whereas the CAH group showed no differences. The incidence of non-M phenotypes (MS, MZ and S) is significantly higher in patients with HCC than in the CAH group and the controls. The mean age of HCC patients with a non-M phenotype is significantly lower than the mean age of HCC patients with an M phenotype.
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