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  • Title: Effect of ergoline derivative VUFB-6638 on the adenohypophysial prolactin concentration in rats.
    Author: Krejcí P, Ausková M, Rezábek K, Bílek J, Semonský M.
    Journal: Endocrinol Exp; 1975 Jan; 9(1):68-72. PubMed ID: 6259.
    Abstract:
    The compound VUFB-6638 (N-/D-6-methyl-8-isoergolin-I-yl/N'-N'-diethylurea hydrogen maleinate) was administered for four consecutive days to lactating rats in daily oral doses of 0.1, 1.0 and 2.0 mg/kg. The adenohypophysial prolactin concentration decreased by 34% to 68%, respectively. Moreover, this compound reduced or even completely suppressed the lactation. In view of the assumed relations between prolactin and breast carcinoma, a potential use of the drug is noted.
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