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  • Title: [Cefotaxime in the treatment of severe infections due to multiresistant Gram-negative bacilli (author's transl)].
    Author: Clumeck N, Van Laethem Y, Vanhoof R, Jaspar N, George G, Rapin M, Butzler JP.
    Journal: Nouv Presse Med; 1981 Feb 26; 10(8):622-4. PubMed ID: 6259606.
    Abstract:
    Cefotaxime was used to treat 33 patients with serious Gram-negative bacillary infections. The dosage varied between 1.5 g and 4 g/day in patients without renal failure. Eighteen patients had urinary tract infections, 6 had pulmonary infections and 10 had miscellaneous infections. Sixteen patients were also bacteremic. Twenty-five infections were due to pathogens resistant to ampicillin, cephalothin, gentamicin and/or tobramycin, in vitro. Fifteen infections had failed to resolve during ampicillin, cefazolin, gentamicin or tobramycin therapy. Thirty-two patients responded favourably (cure or improvement). Four patients developed superinfection with cefotaxime-resistant bacteria. One patient developed mild reversible renal insufficiency. Cefotaxime is a very active cephalosporin with potential use in serious multi-resistant enterobacteria infections.
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