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  • Title: Effects of two histamine H2-receptor blocking drugs on basal levels of gonadotrophins, prolactin, testosterone and oestradiol-17 beta during treatment of duodenal ulcer in male patients.
    Author: Peden NR, Boyd EJ, Browning MC, Saunders JH, Wormsley KG.
    Journal: Acta Endocrinol (Copenh); 1981 Apr; 96(4):564-8. PubMed ID: 6259865.
    Abstract:
    In a study of 51 male patients with duodenal ulcer, treatment with cimetidine was accompanied by an increase in basal levels of serum testosterone. Treatment with ranitidine, a new histamine H2-receptor antagonist, produced no such effect. It is concluded that cimetidine had antiandrogenic activity in man which is separate from the histamine H2-receptor blocking activity.
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