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  • Title: Neuromuscular block produced by polymyxin B: interaction with end-plate channels.
    Author: Fiekers JF.
    Journal: Eur J Pharmacol; 1981 Mar 05; 70(1):77-81. PubMed ID: 6260516.
    Abstract:
    The effect of polymyxin B on the amplitude and kinetics of miniature end-plate currents and acetylcholine-induced current fluctuations was studied in voltage-clamped fibers of the snake. Polymyxin B produced a voltage and concentration dependent reduction in both mean peak MEPC amplitude and the time constant of MEPC decay. A concomitant decrease in mean channel lifetime and single channel conductance indicated that a major mechanism for the neuromuscular block produced by polymyxin B is endplate channel blockade.
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