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  • Title: Involvement of prostaglandins in the local action of endotoxin.
    Author: Kahn A, Brachet E.
    Journal: Prostaglandins Med; 1981 Jan; 6(1):23-8. PubMed ID: 6261284.
    Abstract:
    Endotoxin from Gram-negative bacteria increases the permeability coefficient of albumin in isolated rat mesenteries used as a separating membrane between the two halves of a diffusion cell. Endotoxin also promotes cyclic AMP accumulation in similar mesenteric sheets. These effects are dose-related, and are inhibited by indomethacin. As shown by direct assay, Prostaglandin E-immunoreactive material is synthesized in the presence of endotoxin and is responsible for the increase in albumin permeability and for the increase in cyclic AMP.
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