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  • Title: Immunospecificity of antisera against nonhistone nuclear proteins of human lymphoid cells grown in culture.
    Author: Platz RD, Riordan SE.
    Journal: Cell Differ; 1981 Mar; 10(2):117-23. PubMed ID: 6261962.
    Abstract:
    Rabbit antibodies were obtained to nonhistone protein--DNA complexes (dehistonized chromatin) prepared from two human lymphoblastoid cell lines: the Conception line from an American Burkitt lymphoma and NC-37 from a nonmalignant source. Both antisera showed a high degree of specificity for nuclear proteins of their respective cell lines. This specificity was evident in the reactivity of both whole chromatin and dehistonized chromatin using a quantitative micro-complement fixation assay. The results presented here suggest that DNA present in the antigen is necessary for maintaining the structure of the antigenic site.
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