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  • Title: Antiviral compounds. XVII - Synthesis and in vitro antiviral activity of 1-substituted 2-chloro- and 2-methoxyindole-3-carboxaldehyde thiosemicarbazones.
    Author: Cavrini V, Gatti R, Giovanninetti G, Roveri P, Franchi L, Landini MP.
    Journal: Farmaco Sci; 1981 Feb; 36(2):140-5. PubMed ID: 6262104.
    Abstract:
    A series of indole-3-carboxaldehyde thiosemicarbazones with substituent variations at the 1 and 2 positions were prepared and evaluated for in vitro antiviral activity against vaccinia virus strain IHD and parainfluenza virus type 3, HA-I/CR-8 strain. The inhibitory activity of most compounds was restricted to the vaccinia virus, only compounds (III e) and (III f) being effective against both viruses. Structure-activity relationship are discussed.
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