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  • Title: Pharmacological researches on 2-(7'-theophyllinemethyl)1,3-dioxolane.
    Author: Franzone JS, Reboani C, Fonzo D, Di Carlo R.
    Journal: Farmaco Sci; 1981 Mar; 36(3):201-19. PubMed ID: 6262105.
    Abstract:
    The main pharmacological activities of 2-(7'theophyllinemethyl)-1,3-dioxolane (ABC 12/3), a new theophyllinic derivative, were studied. This compound was shown to possess an extremely high anti-bronchospastic activity in vitro and in vivo, its effectiveness being much greater than that of theophylline; and it also showed a strong activity as an antitussive on experimental cough induced by citric acid or histamine aerosol. However the compound showed little activity on the intestinal smooth muscle, the cardiovascular and the central nervous systems. The acute toxicity of ABC 12/3 is rather low and therefore it should be possible to utilize it for therapeutic purposes in tracheobronchial diseases.
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