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  • Title: Kainic acid stimulation of cerebellar cyclic GMP levels: potentiation by glutamate and related amino acids.
    Author: Foster GA, Roberts PJ.
    Journal: Neurosci Lett; 1981 Apr 09; 23(1):67-70. PubMed ID: 6262684.
    Abstract:
    A number of excitatory amino acids (including kainate and other "excitotoxic" amino acids, (+/-)-ibotenate, and N-methyl-D-aspartate) are able to increase levels of cyclic GMP in cerebellar slices from immature (8-day-old) rats. The response to kainate is markedly potentiated by glutamate and a restricted number of analogues. This phenomenon is not seen with either (+/-)-ibotenate or N-methyl-D-aspartate, and may have implications for the possible mechanisms of cytotoxicity for kainate.
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