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  • Title: Metabolism, oxygen transport, and erythropoietin synthesis in the anemia of thermal injury.
    Author: Sheldon GF, Sanders R, Fuchs R, Garcia J, Schooley J.
    Journal: Am J Surg; 1978 Mar; 135(3):406-11. PubMed ID: 626322.
    Abstract:
    The relationship between metabolism, oxygen transport, and anemia was assessed in burn patients. A significant negative correlation was found between erythrocyte 2,3 DPG, the major modulator of oxygen transport, and erythropoietin synthesis. Simultaneous bioassay and radioimmunoassay for erythropoietin revealed elevated values in the anemic burn patients. Elevated 2,3 DPG values during convalescence from thermal injury may remove the "anemic hypoxia" stimulus to erythropoieitn production, resulting in persistence of the anemia.
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