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  • Title: [Effect of acute administration of high doses of ethanol on the canalicular Na+K+ dependent ATPASE in the isolated and perfused rat liver].
    Author: Bellobuono A, Bellati G, Tempini S, Vitali L, Ideo G.
    Journal: Boll Soc Ital Biol Sper; 1980 Sep 30; 56(18):1833-6. PubMed ID: 6263296.
    Abstract:
    Na+-K+-ATPase in canaliculi-enriched liver plasma membranes was found to be inhibited by high concentration of ethanol (12 mmoles %ml) both in vitro and in vivo; the decrease of Na+-K+-ATPase, which is considered a major factor in the production of bile-salt independent fraction of canalicular bile flow, may be the cause of the previously observed reduction of bile flow after ethanol administration.
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