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  • Title: Inhibition of 2',3'-cyclic nucleotide 3'-phosphodiesterase activity from bovine, human and guinea pig brain.
    Author: Sprinkle TJ, Knerr JR.
    Journal: Brain Res; 1981 Jun 15; 214(2):455-9. PubMed ID: 6263423.
    Abstract:
    The purified oligodendrocyte enzyme 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) obtained from bovine, human and guinea pig brain was inhibited by theophylline, caffeine, cupric chloride and organomercurials using a spectrophotometric assay and 1 mM 2',3'- cyclic cytidylate as the substrate. The observed inhibition by theophylline, caffeine and organomercurials was reversible.
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