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  • Title: Increase of benzodiazepine binding to the membranes isolated in the presence of diazepam.
    Author: Korneyev AY, Factor MI.
    Journal: Eur J Pharmacol; 1981 Apr 24; 71(1):127-30. PubMed ID: 6263645.
    Abstract:
    The preparation of brain cells in the presence of diazepam leads to a 60-70% increase in benzodiazepine receptor density. Diazepam may promote the dissociation of endogenous inhibitors (modulators) and/or retard the dissociation of benzodiazepin receptors from the membrane to the medium. Routinely used procedures for tissue preparation reveal only part of the benzodiazepine receptors originally present in the tissue.
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