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  • Title: Endogenously formed PGE2 mediates the increase in cAMP accumulation in rabbit splenic fibroblasts following alpha-receptor stimulation.
    Author: Jackisch R, Brückner-Schmidt R, Hertting G.
    Journal: Eur J Pharmacol; 1981 Apr 24; 71(1):151-5. PubMed ID: 6263649.
    Abstract:
    Prostaglandin E2 synthesis in rabbit splenic fibroblasts was stimulated by noradrenaline but not by isoprenaline. Noradrenaline, isoprenaline and prostaglandin E2 increased intracellular cAMP accumulation. Noradrenaline-, but not isoprenaline-evoked cAMP accumulation was reduced by indomethacin; only combinations of phentolamine or indomethacin with propranolol abolished the noradrenaline effect. We conclude that the noradrenaline-induced increase in cAMP levels of rabbit splenic fibroblasts was due to stimulation of both alpha- and beta-adrenoceptors. The response to alpha-receptor stimulation was possibly mediated by prostaglandin E2.
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