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  • Title: Histological examination for Z-gene alpha 1-antitrypsin deficiency in small cell anaplastic carcinoma of the lung.
    Author: Sehested M, Hirsch FR, Hou-Jensen K, Hansen HH.
    Journal: Eur J Respir Dis; 1981; 62(2):107-10. PubMed ID: 6263662.
    Abstract:
    Carriers of Z-gene alpha 1-antitrypsin deficiency (A-1-ATD) have characteristic periodic acid Schiff (PAS) positive diastase resistant globules in hepatocytes. In order to determine a possible relationship between Z-gene A-1-ATD and small cell carcinoma of the lung (SCCL), we examined liver blocks from 88 consecutive autopsies performed on patients with SCCL and from a control group of 88 patients with carcinoma not primarily located in the lung or the liver. Histological evidence of Z-gene-A-1-ATD was 4.5% in both groups, corresponding to the expected frequency of Z-gene carriers in a Scandinavian population. It is therefore unlikely that Z-gene A-1-ATD has a role in the development of SCCL.
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