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  • Title: Therapeutic attempts in infants with nonketotic hyperglycinaemia.
    Author: Pueschel SM, Cha CJ, Langon T.
    Journal: J Ment Defic Res; 1981 Mar; 25(Pt 1):61-9. PubMed ID: 6264089.
    Abstract:
    Identical male twins with non-ketotic hyperglycinaemia did not exhibit any development progress while on strychnine treatment. Since other therapeutic attempts with single agents previously had failed in most instances, we tried a combination of various treatment modalities. The results indicated that the administration of glycine receptor antagonist (strychnine) together with a low-protein diet (1.5 gm/kg/day), augmentation of 1-C units (N(5)-formlytetrahydrofolate), and removal of glycine from extracellular fluid (sodium salicylate and sodium benzoate) yielded some clinical improvement and positive biochemical changes in out patients.
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