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  • Title: Linkage of the four gamma subclass heavy chain genes.
    Author: Roeder W, Maki R, Traunecker A, Tonegawa S.
    Journal: Proc Natl Acad Sci U S A; 1981 Jan; 78(1):474-8. PubMed ID: 6264445.
    Abstract:
    The genes for the heavy-chain constant regions of the four gamma subclass immunoglobulins were identified in a set of overlapping mouse DNA fragments representing about 100 kilobase pairs (kb) of the mouse genome that was cloned from bacteriophage lambda libraries of BALB/c mouse embryo DNA. R-loop mapping studies show that the genes are located 5'-C gamma 3-34 kb-C gamma 1-21 kb-C gamma 2b-15 kb-C gamma 2a-3' and lie in the same transcriptional orientation. Two DNA segments, one of 19 kb and another of 15 kb, that surround the C gamma 2b and C gamma 2a genes, respectively, show considerable homology and implicate a tandem duplication mechanism in the evolution of this gene cluster.
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