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  • Title: Reversal of guanethidine- and diethyldithiocarbamate-induced amnesia by peripherally-administered catecholamines.
    Author: Walsh TJ, Palfai T.
    Journal: Pharmacol Biochem Behav; 1981 May; 14(5):713-8. PubMed ID: 6264502.
    Abstract:
    The effect of peripherally-administered catecholamines on guanethidine- and diethyldithiocarbamate-induced amnesia of a PA training in mice was investigated. The amnesic effect of guanethidine could be blocked with 50 mg/kg DA, or 0.75 mg/kg NE when given either before, immediately, or 10 min after but not 90 min following PA. Epinephrine or a lower dose of DA could be attenuate the guanethidine-induced amnesia. The amnesic effect of diethyldithiocarbamate could be blocked with 50 mg/kg DA, 0.75 mg/kg NE or 0.5 mg/kg E when given either before, immediately or 10 ming after but not 90 min following PA. The amnesic effects of these compounds were interpreted in terms of their peripheral antiadrenergic actions.
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