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  • Title: Cyproheptadine in the control of Cushing's disease.
    Author: Hsu TH, Gann DS, Tsan KW, Russell RP.
    Journal: Johns Hopkins Med J; 1981 Aug; 149(2):77-83. PubMed ID: 6265685.
    Abstract:
    A patient with Cushing's disease was treated with cyproheptadine with concomitant remission of the disease for 60 months. Despite clinical improvement and achievement of normal levels of cortisol excretions, her menstruation-related cyclic surge of cortisol secretion was supranormal. The mode of action of cyproheptadine was studied by the administration of metyrapone. Long-term administration of cyproheptadine appeared to normalize excessive adrenocorticotropic hormone (ACTH) production by reducing the frequency and the peak levels of episodic secretion of ACTH.
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