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  • Title: Involvement of mu-receptors in the opioid-induced generation of bursting discharges in hippocampal pyramidal cells.
    Author: Gähwiler BH, Maurer R.
    Journal: Regul Pept; 1981 May; 2(2):91-6. PubMed ID: 6265981.
    Abstract:
    Cultured hippocampal pyramidal cells responded to field stimulation with a short latency excitation followed by a long-lasting inhibition. This sequence was transformed into a bursting response by bath application of 10(-8) M FK 33-824, 10(-6) M (D-Ala)2(D-Leu)5-enkephalin and 10(-5) M bremazocine. Bremazocine and ethylketocyclazocine stereospecifically blocked the effects of FK 33-824. The results indicate that the excitatory responses were predominantly mediated by mu-receptors.
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