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  • Title: Aging of the erythrocyte. IV. Spin-label studies of membrane lipids, proteins and permeability.
    Author: Bartosz G.
    Journal: Biochim Biophys Acta; 1981 Jun 09; 644(1):69-73. PubMed ID: 6266465.
    Abstract:
    Spin-label studies demonstrated age-related alterations of the erythrocyte membrane concerning both lipid and protein components. Decrease in fluidity of membrane lipids correlated with decreased membrane permeability to a hydrophobic spin label TEMPO, permeability to a more hydrophilic TEMPOL being less affected. The rigidification of membrane lipids was much more pronounced in whole membranes than in liposomes composed of membrane lipids, suggesting changes in lipid-protein interactions as an important factor in the decrease of lipid fluidity in aged red cells. ESR spectra of membrane-bound maleimide spin label evidenced alterations in the state of membrane proteins during cell aging in vivo.
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