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  • Title: [Analysis of the excitable properties of an artificial membrane containing amphotericin B in the presence of cationic blockers].
    Author: Markevich NN.
    Journal: Biofizika; 1981; 26(2):260-4. PubMed ID: 6266505.
    Abstract:
    A mathematical model was developed to describe the excitability of the amphotericin B--containing membrane with ionic blockers. The model is equivalent to the Hodgkin--Huxley model of the Na--channel with only one activating particle. A variety of the blockers parameters were evaluated with which the artificial membrane acquires excitable properties (generation of action potential, a self--oscillatory mode of pulse generation, trigger--like changes in the resting potential). The possibilities of constructing artificial excitable membranes with a cooperative activation of conductivity are discussed.
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