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  • Title: Herpes virus inactivation by chemical carcinogens: differential inactivation of herpes simplex viruses by 4-nitroquinoline 1-oxide and related compounds.
    Author: Speelman D, Li JL, Ramanujam VM, Legator MS, Albrecht T.
    Journal: Environ Mutagen; 1981; 3(4):467-76. PubMed ID: 6266824.
    Abstract:
    Treatment of stocks of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) with the chemical carcinogen 4-nitroquinoline 1-oxide (NQO) resulted in inactivation of virus infectivity at rates which were directly dependent on the concentration of NQO and interval of exposure to NQO. HSV-1 strains were more sensitive than HSV-2 strains to inactivation by NQO, although survival curves of both HSV types were multicomponent. Exposure of HSV-2 to a related group of chemicals suggested that the structural specificity required for inactivation of this virus was similar to that established by previous in vivo carcinogenicity tests.
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