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  • Title: Interaction of anticonvulsants with the barbiturate-benzodiazepine-GABA receptor complex.
    Author: Leeb-Lundberg F, Snowman A, Olsen RW.
    Journal: Eur J Pharmacol; 1981 Jun 10; 72(1):125-9. PubMed ID: 6266847.
    Abstract:
    Unlike the anesthetic barbiturate pentobarbital and the anxiolytic pyrazolopyridine etazolate, which enhance [3H]diazepam binding to rat brain membranes, the anticonvulsant barbiturates phenobarbital and metharbital, and also chlormethiazole, at therapeutic concentrations (10-1000 muM), do not stimulate [3H]diazepam binding, but instead block the enhancement by both pentobarbital and etazolate. The same anticonvulsants at similar concentrations inhibit [3H]alpha-dihydropicrotoxinin (DHP) binding suggesting that these anticonvulsants compete for the same receptor sites as pentobarbital and etazolate, designated the barbiturate-picrotoxinin receptor component of the benzodiazepine-GABA receptor complex.
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