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  • Title: Post-amphetamine depression of self-stimulation behavior in rats: prophylactic effects of lithium.
    Author: Predy PA, Kokkinidis L.
    Journal: Neurosci Lett; 1981 May 29; 23(3):343-7. PubMed ID: 6267523.
    Abstract:
    Rats reliably interrupted a photobeam for electrical brain stimulation when electrodes were situated in the substantia nigra. The reinforcing value of electrical brain stimulation diminished, markedly, when animals were exposed to long-term amphetamine treatment and then tested in the absence of the drug. Chronic lithium treatment administered in conjunction with amphetamine protected against the development of the post-amphetamine depression of self-stimulation responding. These findings were not related to drug-induced changes in locomotor activity.
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