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  • Title: [Effect of lithium preparations on the toxic effects of adrenaline].
    Author: Sobieva ZI, Karpova MN, Kryzhanovskaia EG.
    Journal: Biull Eksp Biol Med; 1981 Jun; 91(6):694-6. PubMed ID: 6268223.
    Abstract:
    Experiments on rats have shown that intravenous injection of adrenaline in a dose of 0.3-0.4 mg/kg causes cardiac arrhythmia. In this case the primary arrhythmia developing immediately after adrenaline injection is followed by the recovery of sinusal rhythm which was replaced by the secondary arrhythmia. Apart from arrhythmias, there developed pulmonary edema. The animals died 2--3 minutes after adrenaline injections. Lithium chloride and lithium hydroxybutyrate removed the secondary arrhythmia and pulmonary edema. Lithium hydroxybutyrate has proved to be more effective.
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