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  • Title: Persistent infection of human lymphoid cells with poliovirus and development of temperature-sensitive mutants.
    Author: Carp RI.
    Journal: Intervirology; 1981; 15(1):49-56. PubMed ID: 6268569.
    Abstract:
    Exposure of several spontaneously transformed human lymphoid cell lines to attenuated and virulent types 1 and 2 poliovirus strains led to an initial sharp increase in virus titer followed by a persistent infection. Virus was present as late as 80 passages after infection. The morphology, cell count and viability of virus- and mock-infected cells were similar. Approximately 1% of the cells scored as infectious centers, and the cultures could be cured by specific antiserum. Virus produced during persistent infections initiated with a virus that readily forms plaques at 40 degrees, Mahoney virus, showed an increase in temperature sensitivity and a decrease in plaque size.
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