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  • Title: [Susceptibility of rat thymocyte subpopulations to thymosine affecting their protein synthesis and dexamethasone receptors].
    Author: Lavrinenko IA, Shergin SM, Lozovoi VP.
    Journal: Vopr Med Khim; 1981; 27(3):326-30. PubMed ID: 6269298.
    Abstract:
    Protein synthesis and reception for 1,2-3H-(N)-dexamethasone were studied in A, B, C, D subpopulations of rat thymocytes after treatment with thymosine, cyclic adenosine-3,' 5'-monophosphate (cAMP) and caffeine. Thymosine inhibited the 1,2-3H-(N)-dexamethasone reception in rat thymocyte subpopulations A, B and C by 30-40%, stimulated the protein synthesis in A and B fractions by 30% as well as inhibited the synthesis in D fraction by 14%. Caffeine, administered together with thymosine, inhibited the protein synthesis by 80% in C and D thymocyte subpopulations and - by 47% in B subpopulations. After simultaneous treatment with exogenous cAMP, thymosine and caffeine the protein synthesis was inhibited by 14% in all the thymocyte subpopulations. The data obtained suggest that thymosine and caffeine affect the various lymphocyte T subpopulations, dissimilar in their differentiation.
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