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  • Title: [Aggregation of rhodopsin molecules during damaging exposure of photoreceptor membranes to light].
    Author: Pogozheva ID, Kuznetsov VA, Fedorovich IB, Livshits VA, Ostrovskiĭ MA.
    Journal: Biofizika; 1981; 26(4):692-700. PubMed ID: 6269656.
    Abstract:
    Injuring light induced structural changes in rod outer segment (ROS) membranes are studied using "ST EST spectroscopy" for spin labelled rhodopsin, ESR of lipid spin label and SDS gel-electrophoresis. Free SH-group content of rhodopsin and lipid peroxidation level were simultaneously determined as well. A decrease of rotational mobility of rhodopsin in ROS induced by prolonged illumination is shown to result from irreversible protein aggregation caused by disulfide bond formation between "hydrophobic" SH-groups of rhodopsin. Some decrease of lipid microviscosity and degree of order are found, in contrast to considerable rise in microviscosity due to Fe2+-ascorbate induced lipid peroxidation of ROS membranes. Lipid oxidation is found to accelerate protein aggregation which in its turn influences the state of lipid bilayer.
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