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  • Title: Immunofluorescent staining of nuclear antigen in lymphoid cells transformed by Herpesvirus papio (HVP).
    Author: Schmitz H.
    Journal: J Immunol Methods; 1981; 42(3):337-42. PubMed ID: 6270210.
    Abstract:
    An improved fixation method for antigen detection in lymphoblastoid cells is described. Herpesvirus papio nuclear antigen (HUPNA) could be stained in several transformed lymphoid cell lines by anti-complement immunofluorescence (ACIF). Antibody to HUPNA was detected in many human sera containing antibodies to Epstein-Barr virus capsid and nuclear antigen (EBNA). Rheumatoid arthritis sera showed a high incidence of both anti-EBNA and anti-HUPNA antibodies.
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