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  • Title: DNA gyrase inhibitors block development of Bacillus subtilis bacteriophage SP01.
    Author: Alonso JC, Sarachu AN, Grau O.
    Journal: J Virol; 1981 Sep; 39(3):855-60. PubMed ID: 6270354.
    Abstract:
    SP01 development was inhibited by nalidixic acid and novobiocin in the sensitive host Bacillus subtilis 168M. Inhibition by novobiocin was prevented by a Novr mutation in the cellular DNA gyrase gene. Nalidixic acid inhibition persisted in hosts carrying a Nalr gyrase, but could be overcome by phage mutation. We conclude that SP01 requires for its development subunit B of the host DNA gyrase, but replaces or modifies subunit A.
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