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  • Title: [Hypophosphatemia in total parenteral nutrition (author's transl)].
    Author: Lamouliatte H, Plane D, Quinton A.
    Journal: Sem Hop; ; 57(37-38):1499-503. PubMed ID: 6270815.
    Abstract:
    There is a hypophosphoremic syndrome first discovered without parenteral nutrition (TPN) then on patients with TPN. It appears preferentially in patients suffering from denutrition and receiving an important caloric intake, particularly with glucose. Clinical picture associates psychic, neurologic and respiratory disorders. Phosphatemia is often below 10 mg/l or 0,33 mmol/l, with decrease or even disappearance of phosphatemia. The mechanism is still baby known. During TPN, it occurs an intra-cellular passage of phosphate whose consequences are anomalies in red blood cell metabolism, with decrease of tissular oxygenation, in white cell function, platelet function, central nervous system, muscle, liver and acid-base equilibrium. Treatment must be first preventive with careful control of phosphatemia and systematic intake of phosphates. Curative treatment associates correction of hypophosphatemia and simultaneous decrease of caloric intake.
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