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  • Title: [Effect of cytochrome c on the activity of lysosomal enzymes in the rat liver under hypobaric hypoxia].
    Author: Popov IP.
    Journal: Ukr Biokhim Zh (1978); 1981; 53(5):103-6. PubMed ID: 6270855.
    Abstract:
    Under conditions of three-hour hypobaric hypoxia the total activity of acid phosphatase and DNase in the rat liver somewhat lowers. The activity of free enzymes increases by 27 and 37%, and that of bound ones decreases by 42 and 24 %, respectively. Cytochrome c being introduced to hypoxic animals, the total activity of the enzymes does not significantly change. Under these conditions the activity of free acid phosphatase increases by 16%, and bound one decreases by 24 %. The activity of free acid DNase somewhat rises (by 12%) and that of bound one lowers (by 15%). A preliminary administration of cytochrome c to the organism prevents the development of pronounced changes in the activity of the studied lysosomal enzymes in the liver under grave hypoxia.
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