These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Characteristics of cyclic nucleotide phosphodiesterase and calmodulin in the small intestinal mucosa of rabbits].
    Author: Iurkov VA.
    Journal: Biull Eksp Biol Med; 1981 Jul; 92(7):91-4. PubMed ID: 6271290.
    Abstract:
    Some aspects of the functioning of phosphodiesterase of cyclic nucleotides and calmoduline of the small intestinal mucosa were examined. It was shown that Ca2+ ions virtually have no effect on phosphodiesterase activity of the mucosal homogenate. Cytosol chromatography on a DEAE-cellulose column makes it possible to find an activating effect of calmoduline on phosphodiesterase. Minor quantities of this form of the enzyme might activate the total rate of cAMP hydrolysis with Ca2+ ions for not more than 10%. The author describes calmoduline from the intestinal mucosa as a low-molecular, thermostable protein of acid nature, whose effect can be detected only in the presence of Ca2+ ions.
    [Abstract] [Full Text] [Related] [New Search]