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  • Title: [Activation succinate dehydrogenation in rat liver by noradrenaline, cAMP and acute cooling].
    Author: Kulinskii VI, Kuntsevich AK, Trufanova LV.
    Journal: Biull Eksp Biol Med; 1981 Aug; 92(8):33-4. PubMed ID: 6271294.
    Abstract:
    Administration of noradrenaline in a dose of 11 mumol/kg activates succinate dehydrogenase (SDH) in the rat liver. On incubation of liver homogenate with noradrenaline (10(-6) M), cAMP (10(-6) M) and NaF (10(-2) M), a nonhormonal activator of adenylate cyclase, SDH was found to be activated by 20--30% in all the cases. The effects of noradrenaline and cAMP did not sum up. It seems likely that SDH activation by catecholamines is mediated by cAMP. Acute cooling (--17 degrees C) stimulates SDH via endogenous catecholamines, since this effect is completely reversed by the beta-adrenolytic inderal.
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