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  • Title: [Correlation between renal compensatory hypertrophy and urinary sodium excretion in the ACTH treated rat].
    Author: Reville P, de Laharpe F, Köll-Back MH, Stephan F.
    Journal: C R Seances Soc Biol Fil; 1981; 175(4):468-73. PubMed ID: 6271351.
    Abstract:
    In the rat, renal compensatory hypertrophy (RCH) is enhanced by the administration of ACTH (beta 1-24 corticotrophin) given at a dose of 18 micrograms/100 g. body weight/d. after uninephrectomy. In the rats drinking tap water, the enhancement of RCH by ACTH occurs without any significant change in urinary Na+ excretion. But, in the animals drinking a NaCl solution (9 g/l), ACTH determines a polyuria with hypernatriuria and a more striking increase of RCH positively correlated with the urinary Na+ excretion.
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