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  • Title: Biphasic modulation by ACTH-like peptides of protein synthesis in a cell-free system from rat brain.
    Author: Schotman P, Allaart J.
    Journal: J Neurochem; 1981 Nov; 37(5):1349-52. PubMed ID: 6271926.
    Abstract:
    Brain protein synthesis in a cell-free system was stimulated by 10(-8) M-ACTH1-24. This stimulatory effect was completely inhibited by aurintricarboxylic acid (ATA), an inhibitor of reinitiation of new peptide chains. The N-terminal peptide sequence 4-10 exerted a biphasic modulation of cell-free protein synthesis, i.e., a stimulation at low concentrations (10(-8) and 10(-10) M) and an inhibition at a high concentration (10(-4) M). The D-isomer, ACTH4-10-7-D-phe, also showed a biphasic modulation that, however, was in a direction opposite to that shown by ACTH4-10-7-L-phe at 10(-8) M and 10(-4) M.
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