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  • Title: Are learning and attention related to the sequence of amino acids in ACTH/MSH peptides?
    Author: Sandman CA, Beckwith BE, Kastin AJ.
    Journal: Peptides; 1980; 1(4):277-80. PubMed ID: 6272239.
    Abstract:
    Learning and attention were examined in rats after injections of one of several molecules related to adrenocorticotropic hormone (ACTH) and melanocyte-stimulating hormone (MSH). The initial phase of the learning process was linearly related to the length of the peptide with the smallest fragment (MSH/ACTH 4-10) improving learning the most and the largest molecule (ACTH 1-24) exerting no effect. Later stages of the learning problem, which were sensitive to the attentional state of the organism, resulted in U-shaped relations with the length of the same peptides. Enhancement of attention was significant only for the MSH compounds. These data indicate that some behaviors may be influenced as a function of the redundant information contained in the molecule while other behaviors may be discretely related to the specific conformation of the molecule.
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