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  • Title: Pleiotropic expression of Epstein--Barr virus DNA in human epithelial cells.
    Author: Stoerker J, Parris D, Yajima Y, Glaser R.
    Journal: Proc Natl Acad Sci U S A; 1981 Sep; 78(9):5852-5. PubMed ID: 6272321.
    Abstract:
    We have attempted to establish a system that can be used to study the association of Epstein--Barr virus (EBV) with epithelial cells. Attempts were made to transfect human carcinoma cells with EBV DNA. Successful transfection was confirmed by the expression of EBV-specific early antigen (EA), virus capsid antigen, and the presence of virus DNA. The transfecting preparation contained a mixture of EBV and cellular DNA extracted from two producer cell lines, P3HR-1 and AG-876. Our data suggest that virus DNA obtained from the P3HR-1 nontransforming, EA-inducing strain of EBV was lytically expressed in the epithelial tumor cells. The DNA derived from AG-876 cells, which produce a transforming, non-EA-inducing strain of EBV, also produced a lytic infection.
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