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  • Title: Hormone-sensitive adenylate cyclase in glomerular cells: possible role for inflammatory diseases of the glomerulus.
    Author: Paietta E, Schwarzmeier JD, Simbruner G, Latzka U, Lubec G.
    Journal: Ren Physiol; 1981; 4(2-3):74-8. PubMed ID: 6272378.
    Abstract:
    Using the adenylate cyclase assay after Ross we examined hormone sensitivity of isolated glomerular cells. cAMP production was increased 1.3--1.6-fold by stimulation with isoproterenol, 1.5--1.8 times by prostaglandin E1 and 1.4--1.5 times by histamine. The isoproterenol reaction could be completely inhibited by propranolol, the histamine effect was abolished by the H2-blocking agent cimetidine. As control we applied sodium fluoride, which directly activates the catalytic adenylate cyclase unit, increasing the activity 1.8--2.7 times (depending on the method of homogenization). These findings could reflect some physiological or pathophysiological implications, which are discussed in the present report.
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