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  • Title: [Efficacy of protective effect of aminopropylamino-ethylthiophosphate in neutron beam, gamma or X-irradiation of mice (author's transl)].
    Author: Sedlmeier H, Metzger E, Jentzsch U, Weitzenegger E.
    Journal: Strahlentherapie; 1981 Oct; 157(10):685-91. PubMed ID: 6272452.
    Abstract:
    The efficacy of the radioprotective agent aminopropylamino-ethylthiophosphate (WR 2721) was tested against different kinds of radiation on female NMRI-mice. The animals were divided into 4 groups and were exposed to neutrons as main component, to secondary gamma rays in a tissue-equivalent phantom, to pure gamma rays and to X-rays respectively. The following dose reduction factors have been obtained: 1.05 for neutron-irradiation, 1.33 for gamma irradiation in tissue-equivalent phantom, 1.69 for pure gamma rays and 2.08 for X-rays. The protective agent WR 2721 is apparently more efficient against low LET radiation. The mechanism of protection has been discussed in this respect.
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