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  • Title: [Creation of an avirulent mutant of Aujeszky's disease virus by exposure to 5-bromodeoxyuridine].
    Author: Tatarov G, Gergov P.
    Journal: Vet Med Nauki; 1981; 18(1):3-12. PubMed ID: 6272474.
    Abstract:
    A mutant with new biologic properties has been obtained at the cultivation of a virulent strain of the Aujeszky's disease virus in chick embryo fibroblast cultures, following a definite number of passages. It has proved resistant when culturing at the present of 5-brom-desoxyuridine and 5-iod-2-desoxyuridine, retaining its infections titer. It produces small plaques and destroys cell cultures of a tiny granular structure, the plaque-forming titer being 5. 6X10-7. The mutant has been shown to be avirulent for sheep, suckling pigs, and rabbits. In confers solid and lasting immunity in vaccinated animals which are virus-free and show no virus excretion. The newly obtained MK-35 mutant has proved to be stable in terms of its new biologic properties.
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