These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Modification of the oral radiation death syndrome with combined WR-2721 and misonidazole.
    Author: Grigsby P, Maruyama Y.
    Journal: Br J Radiol; 1981 Nov; 54(647):969-72. PubMed ID: 6272925.
    Abstract:
    In order to investigate the combined use of radioprotective and radiosensitizing chemicals we have used WR--2721 and misonidazole to study their combined chemical toxicity and radiomodifying effects in our model using the oral radiation death (ORD) syndrome as the endpoint. Our data demonstrate that WR-2721 does protect against the ORD syndrome. Misonidazole does not protect against the ORD syndrome. Misonidazole does not sensitize the normal oral cavity to local irradiation. WR-2721 and misonidazole produce additive toxicity when injected simultaneously and the combination can provide an overall protective response to the ORD syndrome. We conclude that the combination may be potentially useful for the treatment of cancers of the oral cavity.
    [Abstract] [Full Text] [Related] [New Search]