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  • Title: The elevation of mouse thymus cell cyclic adenosine monophosphate (cAMP) by lipopolysaccharide.
    Author: Tsien WH, Sampson M, Sheppard H.
    Journal: Immunopharmacology; 1981 Sep; 3(3):253-8. PubMed ID: 6273361.
    Abstract:
    The ability of certain lipopolysaccharide (LPS) preparations to elevate cyclic adenosine monophosphate (cAMP) in mouse thymus cells in the presence of Ro 20-1724, 4-(3-butoxyl 4-methoxybenzyl)-2-imidazolidinone, was not related to the source of supply, bacterial strain, or method of extraction. Under the same conditions adenosine is a potent stimulator of thymus cell cAMP and is, of course, blocked by the further addition of theophylline. When theophylline was added to the LPS preparations with Ro 20-1724, the cAMP production was also blocked. These studies suggested that the observed stimulation of cAMP by LPS preparations was due to adenosine and/or its nucleotides present as contaminants.
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