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  • Title: Intracellular magnesium does not antagonize calcium-dependent acetylcholine secretion.
    Author: Kharasch ED, Mellow AM, Silinsky EM.
    Journal: J Physiol; 1981 May; 314():255-63. PubMed ID: 6273531.
    Abstract:
    1. The effects of intracellular application of Ca and Mg ions on evoked acetylcholine secretion at frog motor nerve terminals were studied. Ca and Mg were applied to the nerve-ending cytoplasm using liposomes as a vehicle. 2. Under conditions in which intracellular application of Ca produced many-fold increased in evoked acetylcholine release. 3. When Mg was applied to the nerve-ending cytoplasm concurrently with Ca, acetylcholine release was further increased above the level produced by introducing Ca alone. 4. The results suggest that intracellular Mg does not antagonize depolarization-secretion coupling and that antagonism of transmitter release by extracellular Mg occurs only at the external surface of the nerve ending.
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