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  • Title: Further studies on mevalonate phosphorylation in neonatal chick brain.
    Author: Linares A, Aguilera JA, García-Peregrín E.
    Journal: Neurochem Res; 1981 Aug; 6(8):893-900. PubMed ID: 6273760.
    Abstract:
    Mevalonate phosphorylation was studied in neonatal chick brain. Formation of phosphorylated derivatives of mevalonic acid increased with the pH in the range assays (5.5-9.5). Phosphomevalonate kinase was completely inactivated after treatment at 50 degree C for 5-10 min, whereas mevalonate kinase was found to retain its activity under the same conditions. Exposure to 65 degree C for 5 min resulted in the inactivation of mevalonate kinase. Both mevalonate-activating enzymes from chick brain were located primarily in the soluble fraction. The amounts of phosphomevalonic acid and pyrophosphomevalonic acid did not show a significant diurnal variation to suggest the presence of a circadian rhythm in either kinase. Cholesterol feeding and fasting had no effect on mevalonate phosphorylation by neonatal chick brain.
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