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  • Title: [Effect of polymyxin B on ion permeability of bacterial membranes].
    Author: Kapitanova NG, Korepanova EA, Gariaev AA, Frolov VN, Antonov VF.
    Journal: Biofizika; 1981; 26(6):1100-2. PubMed ID: 6274432.
    Abstract:
    Effect of polymyxin B on the movement of K+ and H+ in polymyxin-sensitive cells of E. coli under different metabolic states has been studied. It was shown that polymyxin B induced the efflux of K+, decreased the efflux of H+ and inhibited the consumption of oxygen in bacterial cells. The effect of antibiotic on ion movement was independent of respiratory conditions. It was suggested that polymyxin B increased ion permeability and destroyed lipid-protein interactions of the respiratory chain simultaneously.
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