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  • Title: [Adenosine-3',5'-phosphate, adenylate kinase, and cyclic AMP phosphodiesterase of the eye lens during aging].
    Author: Klethi J, Bizec JC, Mandel P.
    Journal: C R Seances Acad Sci III; 1981 Nov 02; 293(8):419-22. PubMed ID: 6274484.
    Abstract:
    Compared to other tissues, the level of cyclic adenosine 3',5' monophosphate (cAMP) of the whole eye lens, at all ages, is rather low. In the epithelial cell layer cAMP content is of the same order of magnitude as in brain tissue but decreases considerably with age. Adenylate cyclase activities measurable only in the epithelial cells diminishes with age. Reduction of cAMP phosphodiesterase activity is observed during aging in lens fibre cells.
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