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  • Title: Medial septal lesions: disruptions of microregulatory patterns and circadian rhythmicity in rats.
    Author: de Castro JM, Stoerzinger A, Barkmeier D, Ellen P.
    Journal: J Comp Physiol Psychol; 1978 Feb; 92(1):71-84. PubMed ID: 627640.
    Abstract:
    The microregulatory patterns of food and water intake were examined in male and female rats bearing medical septal lesions and in sham-operated controls. Medial septal ablation, although not affecting the total amount of food or water ingested, resulted in a profound disruption of the pattern of intake. Circadian rhythmicity was disrupted for a period, returning to normal by 25 days postlesion. Permanent disruptions occurred in feeding patterns in the rats with septal lesions ingested more frequent but smaller meals. There was also a marked increase in food-intake-associated drinking and a decrease in non-food-intake-associated drinking. The results are interpreted to reflect two separate independent effects, a general circadian disruption and an alteration in requlatory behavior produced by a chronic depletion of body fluid.
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